American Board of Surgery Qualifying Exam (ABS QE) Practice Test 2025 - Free Surgery Exam Practice Questions and Study Guide

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What is a key advantage of fractionated radiation therapy?

It targets only tumor cells

It eliminates the need for anesthesia

It allows repair of normal cells and re-oxygenation of the tumor

Fractionated radiation therapy involves delivering radiation in multiple smaller doses rather than one large dose. This approach has a significant advantage because it allows normal healthy cells a greater opportunity to repair themselves between treatment sessions. Additionally, fractionation facilitates the re-oxygenation of tumor cells, which can enhance their sensitivity to the radiation. Tumors often have regions with low oxygen levels (hypoxia), making them more resistant to radiation. By fractionating the treatment, healthy cells can recover while the tumor cells may experience increased oxygenation, improving the overall effectiveness of the radiation treatment.

This fundamental principle is why fractionation is a standard practice in radiation therapy—it optimizes the balance between effectively targeting tumor cells and minimizing damage to surrounding healthy tissues. This strategic approach ultimately contributes to better patient outcomes.

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It enhances chemotherapy effects

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